Novel beta-(imidazol-4-yl)-beta-amino acids: solid-phase synthesis and study of their inhibitory activity against geranylgeranyl protein transferase type I

Ashis K Saha; David W End

doi:10.1016/j.bmcl.2005.01.042

Novel beta-(imidazol-4-yl)-beta-amino acids: solid-phase synthesis and study of their inhibitory activity against geranylgeranyl protein transferase type I

Bioorg Med Chem Lett. 2005 Mar 15;15(6):1713-9. doi: 10.1016/j.bmcl.2005.01.042.

Authors

Ashis K Saha¹, David W End

Affiliation

¹ Janssen Research Foundation, Welsh & McKean Roads, Spring House, PA 19477, USA. Ashis.Saha@praecis.com

PMID: 15745827
DOI: 10.1016/j.bmcl.2005.01.042

Abstract

Solid-phase synthesis of imidazolyl-beta-amino acid derivatives is described. Several analogs demonstrated moderate inhibition of geranylgeranyl protein transferase type I (GGPT I).

MeSH terms

Alkyl and Aryl Transferases / antagonists & inhibitors*
Amino Acids / chemical synthesis*
Amino Acids / pharmacology*
Inhibitory Concentration 50
Models, Chemical
Molecular Structure
Structure-Activity Relationship

Substances

Amino Acids
Alkyl and Aryl Transferases
geranylgeranyltransferase type-I